ERBB4 antibody (AA 1100-1150)

Catalog No. ABIN7452483

This anti-ERBB4 antibody is a Rabbit Polyclonal antibody detecting ERBB4 in IP. Suitable for Human.

Quick Overview for ERBB4 antibody (AA 1100-1150) (ABIN7452483)

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERBB4 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-ERBB4 Antibody

Binding Specificity: AA 1100-1150

Purpose: Rabbit anti-ErbB4 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1100 and 1150

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ERBB4

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Alternative Name: ErbB4

Background: Background: ErbB4 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors homo- or heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ligands preferred by ErbB4 include neuregulins (NRG-2 and NRG-3), heparin-binding EGF-like growth factor, and betacellulin, and epiregulin. ErbB4 appears to be important to mammary gland development and lactation, however its role in breast cancer has not been unequivocally determined.

Gene ID: 2066

NCBI Accession: NP_005226

UniProt: Q15303

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway