NIPBL antibody (AA 1025-1075)

Catalog No. ABIN7452556

This Rabbit Polyclonal antibody specifically detects NIPBL in WB and IP. It exhibits reactivity toward Human.

Quick Overview for NIPBL antibody (AA 1025-1075) (ABIN7452556)

Target: NIPBL (Nipped-B like Protein (NIPBL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NIPBL antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-NIPBL Antibody

Binding Specificity: AA 1025-1075

Purpose: Rabbit anti-NIPBL Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1025 and 1075

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 6 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for NIPBL

Target: NIPBL (Nipped-B like Protein (NIPBL))

Alternative Name: NIPBL

Background: Background: The NIPBL (Nipped B-like) gene was originally identified as a gene mutated in individuals with Cornelia de Lange syndrome (CdLS), a heterogenous developmental disorder associated with multiple anatomical malformations. The NIPBL protein product is also referred to as delangin. It has substantial homology to the D. melanogaster Nipped-B protein which is related to a family of chromosomal adherins that plays a role in sister chromatid adhesion, chromosome condensation, and DNA repair. A study of metaphase spreads from individuals positive and negative for NIPBL mutations revealed an association between NIPBL mutations and precocious sister chromatid separation. This result suggests a function for NIPBL that is similar to its homolog in drosophila.

Gene ID: 25836

NCBI Accession: NP_597677

UniProt: Q6KC79

Pathways: Sensory Perception of Sound, Stem Cell Maintenance