POLA2 antibody (AA 448-498)

Catalog No. ABIN7452745

Product Details anti-POLA2 Antibody

Target: POLA2 (Polymerase (DNA Directed), alpha 2 (70kD Subunit) (POLA2))

Binding Specificity: AA 448-498

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-PolA2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 448 and 498

Isotype: IgG

Application Details

Application Notes:

IP: 5 - 15 μg/mg lysate

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for POLA2

Target: POLA2 (Polymerase (DNA Directed), alpha 2 (70kD Subunit) (POLA2))

Alternative Name: PolA2 (POLA2 Products)

Synonyms: DNA polymerase alpha 2 antibody, F12B7.19 antibody, F12B7_19 antibody, zgc:56124 antibody, zgc:77841 antibody, wu:fb48f05 antibody, AI573378 antibody, DNA polymerase alpha 2, accessory subunit antibody, DNA polymerase alpha 2 antibody, polymerase (DNA directed), alpha 2 antibody, polymerase (DNA directed), alpha 2, accessory subunit L homeolog antibody, polymerase (DNA directed), alpha 2, accessory subunit antibody, POLA2 antibody, pola2 antibody, pola2.L antibody, Pola2 antibody

Background: Background: DNA polymerase alpha is a four-subunit enzyme that exhibits DNA polymerase and primase activity. The four subunits of the heterotetrameric DNA pol alpha are A, B, C, and D. Subunit A displays the catalytic activity while the C and D subunits exhibit the primase activity. DNA polymerase (pol) alpha subunit B (PolA2) is the 70 kDa subunit that may serve to couple the DNA pol alpha-primase complex to the initiation/elongation machinery. DNA pol alpha is the only polymerase in eukaryotic cells that is capable of starting chains de novo.

Gene ID: 23649

NCBI Accession: NP_002680

UniProt: Q14181

Pathways: Telomere Maintenance, Mitotic G1-G1/S Phases, DNA Replication, Protein targeting to Nucleus, Synthesis of DNA, SARS-CoV-2 Protein Interactome