SMARCD1 antibody (AA 250-300)

Catalog No. ABIN7452911

The Rabbit Polyclonal anti-SMARCD1 antibody is suitable to detect SMARCD1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for SMARCD1 antibody (AA 250-300) (ABIN7452911)

Target: SMARCD1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 1 (SMARCD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMARCD1 Antibody

Binding Specificity: AA 250-300

Purpose: Rabbit anti-SMARCD1/BAF60a Antibody, Affinity Purified

Predicted Reactivity: Bovine

Purification: Affinity Purified

Immunogen: between AA 250 and 300

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended. Use rabbit anti-SMARCD1/BAF60a antibody ABIN7452435.

WB: 1:500 - 1:2,500

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SMARCD1

Target: SMARCD1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 1 (SMARCD1))

Alternative Name: SMARCD1/BAF60a

Background: Background: The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. SMARCD1/BAF60a is subunit of the SWI/SNF complex that has been identified as a factor that interacts with nuclear receptors such as the vitamin D receptor and glucocorticoid receptor and a subset of Fos/Jun dimers. SMARCD1 has also been shown to interact with p53 and is suggested to be involved in the tumor suppressor activity of p53. From these findings it has been concluded that SMARCD1 functions as a direct link between transcription factors and SWI/SNF remodeling activity to regulate transcription.

Gene ID: 6602

NCBI Accession: NP_003067

UniProt: Q96GM5