CDK6 antibody (AA 250-300)

Catalog No. ABIN7453059

This anti-CDK6 antibody is a Rabbit Polyclonal antibody detecting CDK6 in WB. Suitable for Human.

Quick Overview for CDK6 antibody (AA 250-300) (ABIN7453059)

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDK6 Antibody

Binding Specificity: AA 250-300

Purpose: Rabbit anti-CDK6 Antibody, Affinity Purified

Predicted Reactivity: Mouse

Purification: Affinity Purified

Immunogen: Between AA 250 and 300

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CDK6

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Alternative Name: CDK6

Background: Background: Cell division protein kinase 6 is a Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation. CDK6 interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. It is involved in initiation and maintenance of cell cycle exit during cell differentiation. Although, it prevents cell proliferation and regulates negatively cell differentiation, it is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). it is also essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. It may play a role in the centrosome organization during the cell cycle phases (PubMed:23918663) [taken from the Universal Protein Resource (UniProt) Q00534].

Gene ID: 1021

UniProt: Q00534

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases