SRRT antibody (AA 826-876)

Catalog No. ABIN7453421

The Rabbit Polyclonal anti-SRRT antibody has been validated for WB, IP and IHC (fp). It is suitable to detect SRRT in samples from Human and Mouse.

Quick Overview for SRRT antibody (AA 826-876) (ABIN7453421)

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRRT antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-SRRT Antibody

Binding Specificity: AA 826-876

Purpose: Rabbit anti-ARS2 Antibody, Affinity Purified

Predicted Reactivity: Zebrafish,X. laevis,Bovine,Orangutan

Purification: Affinity Purified

Immunogen: Between AA 826 and 876

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SRRT

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Alternative Name: ARS2

Background: Background: Arsenate resistance protein 2 (ARS2) acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. ARS2 contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. ARS2 does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewa and does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) [taken from the Universal Protein Resource (UniProt) Q9BXP5].

Gene ID: 51593

NCBI Accession: NP_056992

UniProt: Q9BXP5

Pathways: Notch Signaling, Stem Cell Maintenance