GTF2IRD/TFII-IRD1 (AA 650-700) antibody

Catalog No. ABIN7453501

This Rabbit Polyclonal antibody specifically detects GTF2IRD/TFII-IRD1 in WB, IHC (fp) and IP. It exhibits reactivity toward Human.

Quick Overview for GTF2IRD/TFII-IRD1 (AA 650-700) antibody (ABIN7453501)

Target: GTF2IRD/TFII-IRD1

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunoprecipitation (IP)

Product Details

Binding Specificity: AA 650-700

Purpose: Rabbit anti-GTF2IRD/TFII-IRD1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 650 and 700

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-GTF2IRD/TFII-IRD1 antibody ABIN7449370.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details

Target: GTF2IRD/TFII-IRD1

Background: Background: GTF2IRD1/TFII-IRD1 possesses five helix-loop-helix GTF2I-like repeats and has been shown to bind the GUCE (GTF2IRD1 upstream response element) regulatory motif found in HOXC8, GOOSECOID, and TROPONININ (SLOW) genes. GTF2IRD1/TFII-IRD1 may be involved in skeletal muscle differentiation and myogenesis. Haploinsufficiency of GTF2IRD1/TFII-IRD1 results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.

Gene ID: 9569

NCBI Accession: NP_057412

UniProt: Q9UHL9