IRS2 antibody (AA 1288-1338)

Catalog No. ABIN7453503

This anti-IRS2 antibody is a Rabbit Polyclonal antibody detecting IRS2 in WB, IP and IHC (fp). Suitable for Human.

Quick Overview for IRS2 antibody (AA 1288-1338) (ABIN7453503)

Target: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-IRS2 Antibody

Binding Specificity: AA 1288-1338

Purpose: Rabbit anti-IRS2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1288 and 1338

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-IRS2 antibody ABIN7451820 or ABIN7451821.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for IRS2

Target: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Alternative Name: IRS2

Background: Background: IRS2 (insulin receptor substrate 2) functions as a cytoplasmic link and transducer of insulin receptor (IR) and insulin-like growth factor receptor (IGFR) signaling. As the name implies, IRS2 is a substrate of IR and IGFR tyrosine kinase activity activated by insulin and IGF binding.

Gene ID: 8660

NCBI Accession: NP_003740

UniProt: Q9Y4H2

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process