Cyclin C antibody (AA 233-283)

Catalog No. ABIN7453580

The Rabbit Polyclonal anti-Cyclin C antibody has been validated for WB, IP and IHC (fp). It is suitable to detect Cyclin C in samples from Human.

Quick Overview for Cyclin C antibody (AA 233-283) (ABIN7453580)

Target: Cyclin C (CCNC)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin C antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-Cyclin C Antibody

Binding Specificity: AA 233-283

Purpose: Rabbit anti-Cyclin C Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Chicken,Bovine

Purification: Affinity Purified

Immunogen: between AA 233 and 283

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 to 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Cyclin C

Target: Cyclin C (CCNC)

Alternative Name: Cyclin C

Background: Background: Cyclin C is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression. Cyclins exhibit periodicity in their expression and activity which is regulated transcriptionally and post-transcriptionally via phosphorylation and ubiquitination. Cyclin C associates with cyclin-dependent kinase 8 (CDK8). It is also a component of the Mediator complex, a coactivator complex that provides a scaffold to link gene-specific transcription factors to RNA polymerase II and the general transcription machinery.

Gene ID: 892

NCBI Accession: NP_005181

UniProt: P24863

Pathways: Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha