The Rabbit Monoclonal anti-RUNX3 antibody (Clone BLR122H) (ABIN7454015) specifically detects RUNX3 in WB, IHC, FACS, IP and ICC.
The antibody is reactive with Human samples.
RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of RUNX3 and CBFB forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. This complex binding can either activate or suppress transcription to control cellular proliferation and/or differentiation, in particular cytotoxic T cell differentiation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13761].