ERCC3 antibody (AA 575-625)

Catalog No. ABIN7454400

This Rabbit Polyclonal antibody specifically detects ERCC3 in IP and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for ERCC3 antibody (AA 575-625) (ABIN7454400)

Target: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC3 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-ERCC3 Antibody

Binding Specificity: AA 575-625

Purpose: Rabbit anti-ERCC3 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Zebrafish,Bovine,Orangutan

Purification: Affinity Purified

Immunogen: between AA 575 and 625

Isotype: IgG

Application Details

Application Notes:

IHC: 1:2,000 to 1:10,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-ERCC3 antibody A301-337A.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ERCC3

Target: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Alternative Name: ERCC3

Background: Background: ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3'-5' DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.

Gene ID: 2071

NCBI Accession: NP_000113

UniProt: P19447

Pathways: DNA Damage Repair