PSMD2 antibody (AA 50-100)

Catalog No. ABIN7454976

This Rabbit Polyclonal antibody specifically detects PSMD2 in WB, IP and IHC (fp). It exhibits reactivity toward Human and Mouse.

Quick Overview for PSMD2 antibody (AA 50-100) (ABIN7454976)

Target: PSMD2 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 2 (PSMD2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-PSMD2 Antibody

Binding Specificity: AA 50-100

Purpose: Rabbit anti-PSMD2 Antibody, Affinity Purified

Predicted Reactivity: Rat,Bovine,Orangutan

Purification: Affinity Purified

Immunogen: Between AA 50 and 100

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PSMD2

Target: PSMD2 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 2 (PSMD2))

Alternative Name: PSMD2

Background: Background: PSMD2 [proteasome (prosome, macropain) 26S subunit, non-ATPase, 2] is a subunit of the 26 S proteasome. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD2 is a subunit of the 19S regulator lid, which is responsible for substrate recognition and binding [taken from NCBI Entrez Gene (Gene ID: 5708)].

Gene ID: 5708

NCBI Accession: NP_002799

UniProt: Q13200

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway