CSF1R antibody
Quick Overview for CSF1R antibody (ABIN7457933)
Target
See all CSF1R AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Purification
- Purified
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- Low Endotoxin: Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
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Isotype
- IgG2a, kappa
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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Matching Isotype Control: AF/LE Purified Rat IgG2a, κ Isotype Control (ABIN7469836)
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Restrictions
- For Research Use only
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Concentration
- 0.5 mg/mL
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Buffer
- PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE)
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Preservative
- Azide free
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Storage
- 4 °C
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Storage Comment
- Store at 2~8°C. Do not freeze.
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- CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
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Alternative Name
- CD115
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Background
- Macrophage colony-stimulating factor 1 receptor,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115,Csf1r,Csfmr,Fms,CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
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Gene ID
- 12978
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UniProt
- P09581
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Pathways
- RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
Target
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