UNG antibody

Catalog No. ABIN7464537

This Rabbit Polyclonal antibody specifically detects UNG in WB, IF, ICC and MA. It exhibits reactivity toward Human.

Quick Overview for UNG antibody (ABIN7464537)

Target: UNG (Uracil-DNA Glycosylase (UNG))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNG antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Multiplex Assay (MA)

Grade: KO Validated

Product Details anti-UNG Antibody

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human UNG. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLa

Validation: KO/KD

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.71 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Alternative Name: uracil DNA glycosylase

Background: Uracil DNA glycosylase , DGU , HIGM4 , HIGM5 , UDG , UNG1 , UNG15 , UNG2,This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. [provided by RefSeq]

Molecular Weight: 35 kDa

Gene ID: 7374

UniProt: P13051

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response