TINF2 antibody

Catalog No. ABIN7464645

This Rabbit Polyclonal antibody specifically detects TINF2 in WB. It exhibits reactivity toward Human.

Quick Overview for TINF2 antibody (ABIN7464645)

Target: TINF2 (TIN2) (TERF1 Interacting Nuclear Factor 2 (TIN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TINF2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TINF2 Antibody

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Full length human TIN2 Recombinant protein.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: IMR32 nuclear extract

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for TINF2

Target: TINF2 (TIN2) (TERF1 Interacting Nuclear Factor 2 (TIN2))

Alternative Name: TERF1 interacting nuclear factor 2

Background: TERF1 interacting nuclear factor 2 , DKCA3 , TIN2,This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin, it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq]

Molecular Weight: 50 kDa

Gene ID: 26277

UniProt: Q9BSI4

Pathways: Cell Division Cycle, Telomere Maintenance, Regulation of Carbohydrate Metabolic Process