TP53BP1 antibody (C-Term)

Catalog No. ABIN7464819

This Rabbit Polyclonal antibody specifically detects TP53BP1 in WB, IHC, IF, ICC and IHC (p). It exhibits reactivity toward Human.

Quick Overview for TP53BP1 antibody (C-Term) (ABIN7464819)

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TP53BP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: KO Validated

Product Details anti-TP53BP1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human, Mouse

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide corresponding to the carboxy-terminus of h53BP1, conjugated to a carrier protein.

Isotype: IgG

Application Details

Application Notes: Suggested starting dilutions are as follows: WB: 1:500-1:3000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Comment:

Positive Control: Neuro 2A , C8D30 , NIH-3T3 , HeLa

Validation: KO/KD

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.83 mg/mL

Buffer: PBS, No Preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for TP53BP1

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Alternative Name: tumor protein p53 binding protein 1

Background: Tumor protein p53 binding protein 1 , 53BP1 , TDRD30 , p202 , p53BP1,P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.

Molecular Weight: 214 kDa

Gene ID: 7158

UniProt: Q12888

Pathways: DNA Damage Repair