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TDG antibody (N-Term)

The Rabbit Polyclonal anti-TDG antibody has been validated for WB. It is suitable to detect TDG in samples from Human.
Catalog No. ABIN7464910

Quick Overview for TDG antibody (N-Term) (ABIN7464910)

Target

See all TDG Antibodies
TDG (Thymine-DNA Glycosylase (TDG))

Reactivity

  • 50
  • 19
  • 11
  • 2
  • 2
Human

Host

  • 38
  • 12
Rabbit

Clonality

  • 41
  • 10
Polyclonal

Conjugate

  • 44
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This TDG antibody is un-conjugated

Application

  • 40
  • 14
  • 11
  • 11
  • 6
  • 6
  • 5
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB)

Grade

KO Validated
  • Binding Specificity

    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Cross-Reactivity

    Human, Rat

    Purification

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the N-terminus region of human TDG. The exact sequence is proprietary.

    Isotype

    IgG
  • Application Notes

    WB: 1:5000-1:20000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Comment

    Positive Control: rat brain , HeLa , TDG-transfected 293T

    Validation: KO/KD, Overexpression

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

    Preservative

    Thimerosal (Merthiolate)

    Precaution of Use

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    TDG (Thymine-DNA Glycosylase (TDG))

    Alternative Name

    thymine DNA glycosylase

    Background

    Thymine DNA glycosylase , hTDG,The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]

    Molecular Weight

    46 kDa

    Gene ID

    6996

    UniProt

    Q13569

    Pathways

    DNA Damage Repair, Chromatin Binding
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