TDG antibody (N-Term)
Quick Overview for TDG antibody (N-Term) (ABIN7464910)
Target
See all TDG AntibodiesReactivity
Host
Clonality
Conjugate
Application
Grade
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Binding Specificity
- N-Term
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Cross-Reactivity
- Human, Rat
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Purification
- Purified by antigen-affinity chromatography.
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Immunogen
- Recombinant protein encompassing a sequence within the N-terminus region of human TDG. The exact sequence is proprietary.
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Isotype
- IgG
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Application Notes
- WB: 1:5000-1:20000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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Comment
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Positive Control: rat brain , HeLa , TDG-transfected 293T
Validation: KO/KD, Overexpression
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
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Preservative
- Thimerosal (Merthiolate)
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Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- TDG (Thymine-DNA Glycosylase (TDG))
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Alternative Name
- thymine DNA glycosylase
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Background
- Thymine DNA glycosylase , hTDG,The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]
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Molecular Weight
- 46 kDa
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Gene ID
- 6996
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UniProt
- Q13569
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Pathways
- DNA Damage Repair, Chromatin Binding
Target
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