COPS5 antibody

Catalog No. ABIN7464988

The Mouse Monoclonal anti-COPS5 antibody is suitable to detect COPS5 in samples from Mouse. It has been validated for WB, IHC and IP.

Quick Overview for COPS5 antibody (ABIN7464988)

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This COPS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 6C3-38

Product Details anti-COPS5 Antibody

Cross-Reactivity: Human, Mouse

Purification: Protein G purified

Immunogen: The full-length mouse JAB-1 gene expressed in E. coli.

Isotype: IgG2a

Application Details

Application Notes: WB: 0.5 - 1 μg/mL. IP: 0.5 - 1 μg/mL. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: 293 cell lysate

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, No Preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for COPS5

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Alternative Name: COP9 signalosome subunit 5

Background: COP9 signalosome subunit 5 , CSN5 , JAB1 , MOV-34 , SGN5,The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Molecular Weight: 38 kDa

Gene ID: 10987

UniProt: Q92905

Pathways: Cell Division Cycle