TRPC4AP antibody (N-Term)

Catalog No. ABIN7465522

The Rabbit Polyclonal anti-TRPC4AP antibody is suitable to detect TRPC4AP in samples from Human. It has been validated for WB.

Quick Overview for TRPC4AP antibody (N-Term) (ABIN7465522)

Target: TRPC4AP (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPC4AP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRPC4AP Antibody

Binding Specificity: N-Term

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human TRPC4AP. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: A549

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for TRPC4AP

Target: TRPC4AP (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP))

Alternative Name: transient receptor potential cation channel subfamily C member 4 associated protein

Background: Transient receptor potential cation channel subfamily C member 4 associated protein , C20orf188 , PPP1R158 , TRRP4AP , TRUSS,Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Molecular Weight: 91 kDa

Gene ID: 26133

UniProt: Q8TEL6