CDK7 antibody

Catalog No. ABIN7466370

This Rabbit Polyclonal antibody specifically detects CDK7 in WB, IP and IHC (p). It exhibits reactivity toward Human.

Quick Overview for CDK7 antibody (ABIN7466370)

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CDK7 Antibody

Specificity: IP/MS validation was supported by references (PMID:30377406)

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Full length human CDK7 Recombinant protein.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validation: IP/MS

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.26 mg/mL

Buffer: 1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for CDK7

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Alternative Name: cyclin dependent kinase 7

Background: Cyclin dependent kinase 7 , CAK , CAK1 , CDKN7 , HCAK , MO15 , STK1 , p39MO15,The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq]

Molecular Weight: 39 kDa

Gene ID: 1022

UniProt: P50613

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase