CREM antibody

Catalog No. ABIN7466965

The Rabbit Polyclonal anti-CREM antibody has been validated for WB, IF and ICC. It is suitable to detect CREM in samples from Human.

Quick Overview for CREM antibody (ABIN7466965)

Target: CREM (CAMP Responsive Element Modulator (CREM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREM antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-CREM Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CREM. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Neuro2A , GL261 , PC-12 , Rat2 , NT2D1

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.31 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for CREM

Target: CREM (CAMP Responsive Element Modulator (CREM))

Alternative Name: cAMP responsive element modulator

Background: CAMP responsive element modulator , CREM-2 , ICER , hCREM-2,This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq]

Molecular Weight: 39 kDa

Gene ID: 1390

UniProt: Q03060

Pathways: Retinoic Acid Receptor Signaling Pathway