KCNN4 antibody (AA 325-427)

Catalog No. ABIN719786

There are 2+ publications for this product available. The Rabbit Polyclonal anti-KCNN4 antibody is suitable to detect KCNN4 in samples from Human and Rat. It has been validated for WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for KCNN4 antibody (AA 325-427) (ABIN719786)

Target: KCNN4 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNN4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-KCNN4 Antibody

Binding Specificity: AA 325-427

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KCNN4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-KCNN4 antibody (ABIN719786)

Lively, Lam, Wong, Schlichter: "Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels." in: Frontiers in cellular neuroscience, Vol. 12, pp. 115, (2018) (PubMed).

Zhang, Yang, Yin, Yi, Shen, Zhao, Zhu, Liu: "Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154471, (2016) (PubMed).

Target Details for KCNN4

Target: KCNN4 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4))

Alternative Name: KCNN4

Background:

Synonyms: IK1, SK4, KCA4, hSK4, IKCA1, hKCa4, KCa3.1, hIKCa1, Intermediate conductance calcium-activated potassium channel protein 4, SKCa 4, SKCa4, Putative Gardos channel, KCNN4

Background: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.

Gene ID: 3783

UniProt: O15554