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Retinoblastoma Binding Protein 4 antibody

This anti-Retinoblastoma Binding Protein 4 antibody is a Rabbit Polyclonal antibody detecting Retinoblastoma Binding Protein 4 in WB, IF, IHC (p), ICC and IHC (wm). Suitable for Human.
Catalog No. ABIN7468874

Quick Overview for Retinoblastoma Binding Protein 4 antibody (ABIN7468874)

Target

See all Retinoblastoma Binding Protein 4 (RBBP4) Antibodies
Retinoblastoma Binding Protein 4 (RBBP4)

Reactivity

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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This Retinoblastoma Binding Protein 4 antibody is un-conjugated

Application

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Whole Mount) (IHC (wm))
  • Cross-Reactivity

    Human, Zebrafish (Danio rerio)

    Purification

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human RbAp48. The exact sequence is proprietary.

    Isotype

    IgG
  • Application Notes

    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Comment

    Positive Control: A431 , SH-SY5Y nuclear extract Validation: Orthogonal

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    0.65 mg/mL

    Buffer

    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

    Preservative

    Thimerosal (Merthiolate)

    Precaution of Use

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    Retinoblastoma Binding Protein 4 (RBBP4)

    Alternative Name

    RB binding protein 4, chromatin remodeling factor

    Background

    Synonyms: RB binding protein 4, chromatin remodeling factor , NURF55 , RBAP48 , lin-53

    Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

    Molecular Weight

    48 kDa

    Gene ID

    5928

    UniProt

    Q09028

    Pathways

    Cell Division Cycle, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus
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