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Retinoblastoma Binding Protein 4 antibody (AA 1-425)

This Mouse Monoclonal antibody specifically detects Retinoblastoma Binding Protein 4 in WB, IHC, IF, IP and ICC. It exhibits reactivity toward Human.
Catalog No. ABIN7468875

Quick Overview for Retinoblastoma Binding Protein 4 antibody (AA 1-425) (ABIN7468875)

Target

See all Retinoblastoma Binding Protein 4 (RBBP4) Antibodies
Retinoblastoma Binding Protein 4 (RBBP4)

Reactivity

  • 53
  • 45
  • 41
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
Human

Host

  • 60
  • 7
  • 2
Mouse

Clonality

  • 50
  • 19
Monoclonal

Conjugate

  • 33
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Retinoblastoma Binding Protein 4 antibody is un-conjugated

Application

  • 30
  • 21
  • 17
  • 17
  • 14
  • 14
  • 10
  • 8
  • 7
  • 6
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone

13D10
  • Binding Specificity

    • 15
    • 10
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-425

    Cross-Reactivity

    Human

    Purification

    Protein G purified

    Immunogen

    The complete coding region (amino acids 1-425) of RbAp48 expressed in E. coli.

    Isotype

    IgG2b
  • Application Notes

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Comment

    Positive Control: HeLa nuclear extract , SH-SY-5Y , SH-SY-5Y nuclear extract Validation: Orthogonal

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    PBS, No Preservative

    Preservative

    Without preservative

    Storage

    4 °C,-20 °C

    Storage Comment

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    Retinoblastoma Binding Protein 4 (RBBP4)

    Alternative Name

    RB binding protein 4, chromatin remodeling factor

    Background

    Synonyms: RB binding protein 4, chromatin remodeling factor , NURF55 , RBAP48 , lin-53

    Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

    Molecular Weight

    48 kDa

    Gene ID

    5928

    UniProt

    Q09028

    Pathways

    Cell Division Cycle, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus
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