Retinoblastoma Binding Protein 4 antibody (AA 1-425)
Quick Overview for Retinoblastoma Binding Protein 4 antibody (AA 1-425) (ABIN7468877)
Target
See all Retinoblastoma Binding Protein 4 (RBBP4) AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
-
-
Binding Specificity
- AA 1-425
-
Cross-Reactivity
- Human, Mouse
-
Purification
- Protein G purified
-
Immunogen
- The complete coding region (amino acids 1-425) of RbAp48 expressed in E. coli.
-
Isotype
- IgG2b
-
-
-
-
Application Notes
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
-
Comment
-
Positive Control: MOLT4 , HeLa , LB22 , SH-SY5Y , SH-SY5Y nuclear extract Validation: Orthogonal
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Concentration
- 1 mg/mL
-
Buffer
- PBS, No Preservative
-
Preservative
- Without preservative
-
Storage
- 4 °C,-20 °C
-
Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
- Retinoblastoma Binding Protein 4 (RBBP4)
-
Alternative Name
- RB binding protein 4, chromatin remodeling factor
-
Background
-
Synonyms: RB binding protein 4, chromatin remodeling factor , NURF55 , RBAP48 , lin-53
Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
-
Molecular Weight
- 48 kDa
-
Gene ID
- 5928
-
UniProt
- Q09028
-
Pathways
- Cell Division Cycle, Mitotic G1-G1/S Phases, Stem Cell Maintenance, Chromatin Binding, Protein targeting to Nucleus
Target
-