Retinoblastoma Binding Protein 8 antibody

Catalog No. ABIN7468880

This anti-Retinoblastoma Binding Protein 8 antibody is a Mouse Monoclonal antibody detecting Retinoblastoma Binding Protein 8 in WB, IP, ICC, IF, PLA and ChIP. Suitable for Human.

Quick Overview for Retinoblastoma Binding Protein 8 antibody (ABIN7468880)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Proximity Ligation Assay (PLA), Chromatin Immunoprecipitation (ChIP)

Grade: KO Validated

Clone: 1-90E-09

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Cross-Reactivity: Human, Mouse

Purification: Protein G purified

Immunogen: Human CtIP

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:1000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validation: KO/KD, Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, No preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: RB binding protein 8, endonuclease

Background:

Synonyms: RB binding protein 8, endonuclease , COM1 , CTIP , JWDS , RIM , SAE2 , SCKL2

Background: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Molecular Weight: 102 kDa

Gene ID: 5932

UniProt: Q99708

Pathways: Cell Division Cycle, DNA Damage Repair