XPC antibody

Catalog No. ABIN7469198

This anti-XPC antibody is a Mouse Monoclonal antibody detecting XPC in WB, ICC, IHC (p) and IF. Suitable for Human.

Quick Overview for XPC antibody (ABIN7469198)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This XPC antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: 3-26

Product Details anti-XPC Antibody

Cross-Reactivity: Human, Mouse

Purification: Protein G purified

Immunogen: Recombinant XPC purified from E. coli

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLa whole cell extract

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.15 mg/mL

Buffer: PBS, No Preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Alternative Name: XPC complex subunit, DNA damage recognition and repair factor

Background:

Synonyms: XPC complex subunit, DNA damage recognition and repair factor , RAD4 , XP3 , XPCC , p125

Background: The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]

Molecular Weight: 106 kDa

Gene ID: 7508

UniProt: Q01831

Pathways: p53 Signaling, DNA Damage Repair