Recombinant MSH2 antibody (full length)

Catalog No. ABIN7470646

The Mouse Monoclonal anti-MSH2 antibody (Clone 902M) (ABIN7470646) specifically detects MSH2 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant MSH2 antibody (full length) (ABIN7470646)

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MSH2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: 902M

Product Details anti-MSH2 Antibody

Binding Specificity: full length

Purpose: MSH2 antibody (902M)

Immunogen: Recombinant full-length human MSH2 protein

Isotype: IgG2a, kappa

Application Details

Application Notes: IHC 1:100-1:200

Comment:

Positive Control: Tonsil: Virtually all mantle zone B-cells must show an at least weak to moderate nuclear staining. A moderate to strong nuclear staining must be seen in the germinal centre B-cells.

Product Description: MSH2 antibody validated for immunohistochemistry on 76 different Normal Tissues

Negative Control: Colon adenocarcinoma with previously documented loss of MSH2 expression: no nuclear staining should be seen in cancer cells, while a nuclear staining must be seen in stromal and inflammatory cells.

Protocol: Freshly cut sections should be used (less than 10 days between cutting and staining). Heat-induced antigen retrieval for 5 minutes in an autoclave at 121 °C in pH 7,8 Target Retrieval Solution buffer. Apply the antibody at a dilution of 1:150 at 37 °C for 60 minutes.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 ° C. Antibody is stable for 24 months. Non- hazardous.

Expiry Date: 24 months

Target Details for MSH2

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Alternative Name: MSH2

Background: Gene Alias: BAT26, COCA1, DNA mismatch repair protein Msh2, FCC1, hMSH2, HNPCC1, LCFS2, MSH2, MutS homolog 2, MutS homolog 2 colon cancer nonpolyposis type 1, MutS protein homolog 4

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response