LIFR antibody (PE)

Catalog No. ABIN7505851

The Mouse Monoclonal anti-LIFR antibody is suitable to detect LIFR in samples from Human. It has been validated for FACS.

Quick Overview for LIFR antibody (PE) (ABIN7505851)

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LIFR antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 12D3

Product Details anti-LIFR Antibody (PE)

Purpose: Anti-Hu CD118 PE

Characteristics: The mouse monoclonal antibody 12D3 recognizes an extracellular epitope of CD118, a transmembrane glycoprotein, which associates with CD130 to form the functional high affinity LIF receptor.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: human recombinant soluble CD118-Fc

Isotype: IgG1, kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 4-10 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze,Protect from prolonged exposure to light

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for LIFR

Target: LIFR (Leukemia Inhibitory Factor Receptor alpha (LIFR))

Alternative Name: CD118

Background: LIF receptor subunit alpha,CD118 (LIFR alpha) is a type I transmembrane glycoprotein of the cytokine receptor family, which associates noncovalently with CD130 to form the functional high affinity LIF receptor, which also acts as an oncostatin M receptor. CD118 alone binds LIF with low affinity. A secreted form of CD118 results from alternative splicing, and may have inhibitory effect, as it also binds LIF, although with low affinity. CD118 is not expressed on lymphocytes, but it is widely expressed outside the immune system. Soluble CD118 level rises during pregnancy, in parallel with a drop in circulating LIF levels.,LIFR alpha, SWS, SJS2, STWSm, gp190

Gene ID: 3977

UniProt: P42702

Pathways: JAK-STAT Signaling, Growth Factor Binding