CD28 antibody (APC-Cy7)

Catalog No. ABIN7529062

The APC-Cy7-conjugated Mouse Monoclonal anti-CD28 antibody (Clone 28-2) (ABIN7529062) specifically detects CD28 in FACS. The antibody is reactive with Human samples.

Quick Overview for CD28 antibody (APC-Cy7) (ABIN7529062)

Target: CD28

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD28 antibody is conjugated to APC-Cy7

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: 28-2

Product Details anti-CD28 Antibody (APC-Cy7)

Purpose: CD28 APC-Cyanine7 Antibody

Characteristics: The clone 28.2, a mouse monoclonal antibody selectively recognizes a 44 kDa type I cell surface glycoprotein known as CD28. It is expressed by all T cells and acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, B7-1 (CD80) and B7-2 (CD86), which are primarily expressed by the activated B cells as well as other antigen-presenting cells. CD28-CD28 ligands signaling induces TCR functional activation resulting T cell proliferation, production of higher levels of IL-2 and enhancing T cell cytotoxicity.

Purification: Purified

Purity: >95 %

Immunogen: Murine T cells overexpressing human CD28 cDNA

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CD28

Target: CD28

Alternative Name: CD28

Gene ID: 940

UniProt: P10747

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response