Cyclin D1 antibody

Catalog No. ABIN7529091

The Mouse Monoclonal anti-Cyclin D1 antibody has been validated for FACS. It is suitable to detect Cyclin D1 in samples from Human.

Quick Overview for Cyclin D1 antibody (ABIN7529091)

Target: Cyclin D1 (CCND1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cyclin D1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: C-D1A5

Product Details anti-Cyclin D1 Antibody

Purpose: Cyclin D1 Unconjugated Antibody

Characteristics: The clone C-D1A5, a mouse monoclonal antibody selectively binds to ~34 kD protein is encoded by the CCND1 gene known as Cyclin D1. It is expressed in all adult human tissues except for cells derived from bone marrow stem cell lines (both lymphoid and myeloid), Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptional co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer cells.

Purification: Purified

Purity: >95 %

Immunogen: Human full length recombinant cyclin D1 protein

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for Cyclin D1

Target: Cyclin D1 (CCND1)

Alternative Name: Cyclin D1

Gene ID: 5788

NCBI Accession: NM_002838

UniProt: P08575

Pathways: PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling