CTLA4 antibody (iFluor™488)

Catalog No. ABIN7539512

The Mouse Monoclonal anti-CTLA4 antibody is suitable to detect CTLA4 in samples from Human. It has been validated for FACS.

Quick Overview for CTLA4 antibody (iFluor™488) (ABIN7539512)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTLA4 antibody is conjugated to iFluor™488

Application: Flow Cytometry (FACS)

Grade: GMP Grade (Analyte)

Clone: A3-4H2

Product Details anti-CTLA4 Antibody (iFluor™488)

Purpose: CD152 iFluor488 Antibody

Characteristics: The clone A3.4H2, a mouse monoclonal antibody, selectively binds to the human 33- kDa member of the immunoglobulin superfamily, also known as Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CD152 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is transiently expressed on activated CD28+ T cells and binds to CD80 and CD86 present on antigen presenting cells (APC) with high avidity. Intracellular CD152 is also expressed on regulatory T cells and contributes to their inhibitory function.

Purification: Purified

Purity: >95 %

Immunogen: Activated T cells

Isotype: IgG2a, kappa

Application Details

Application Notes: FC: 5 µL/test We recommend that every lab carries out an initial titration study before running your samples to ensure that the optimal concentration is selected for your application.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.2, 0.09 % Sodium azide and 0.2 % (w/v) BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CD152

Gene ID: 929

UniProt: P08571

Pathways: Cancer Immune Checkpoints