SIGLEC10 antibody (Extracellular Domain) (APC)

Catalog No. ABIN7540465

This anti-SIGLEC10 antibody is a Mouse Monoclonal antibody detecting SIGLEC10 in FACS. Suitable for Human.

Quick Overview for SIGLEC10 antibody (Extracellular Domain) (APC) (ABIN7540465)

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIGLEC10 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: 5G6

Product Details anti-SIGLEC10 Antibody (APC)

Binding Specificity: Extracellular Domain

Purpose: Anti-Hu SIGLEC10 APC

Specificity: The mouse monoclonal antibody 5G6 recognizes an extracellular epitope of human SIGLEC10, a sialic acid-binding lectin expressed on subsets of human leucocytes.

Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: SIGLEC10 extracellular domain fused with human IgG1 Fc fragment

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for SIGLEC10

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Alternative Name: SIGLEC10

Background:

NCBI Full Gene Name: sialic acid binding Ig like lectin 10

Description: SIGLEC10 is a CD33-related receptor of sialoglycans, expressed on eosinophils, monocytes, a subpopulation of NK cells, and at lower level on B cells. Its murine ortholog is Siglec G. SIGLEC10 seems to act as an immunomodulatory receptor, which binds to VAP-1, a glycoprotein expressed on endothelium under inflammatory conditions. Another ligand of SIGLEC10 is CD24, a marker of poorer prognosis in carcinomas.

Other names: PRO940, SGL2

Gene name: SIGLEC10

Gene ID: 89790

UniProt: Q96LC7