DREAM antibody

Catalog No. ABIN7540487

Supplier Product No.: 200-301-f81

This Mouse Monoclonal antibody specifically detects DREAM in WB, IHC and FM. It exhibits reactivity toward Rat.

Quick Overview for DREAM antibody (ABIN7540487)

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This DREAM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Clone: S66-38

Product Details anti-DREAM Antibody

Supplier Product No.: 200-301-f81

Supplier: Rockland

Purpose: KChlP3 K+ channel Antibody

Cross-Reactivity (Details): A BLAST analysis was used to suggest cross-reactivity with KChlP3 K+ channel from Mouse, Human, and Rat based on 100 % homology with the immunizing sequence.

Purification: Anti-KChlP3 K+ channel Antibody was purified by Protein G chromatography.

Sterility: Sterile filtered

Immunogen: KChlP3 K+ channel Antibody was produced in mice by repeated immunizations raised against a fusion protein of full length of rat Calsenillin/DREAM/KChIP3.

Isotype: IgG2a

Application Details

Application Notes:

Immunohistochemistry_Dilution: 0.1-1.0 μg/mL

IF_Microscopy_Dilution: 1.0-10 μg/mL

Western_Blot_Dilution: 1 μg/mL

Comment:

Anti-KChlP3 K+ channel Antibody is tested for use in WB and IHC. Expect a band approximately ~34kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for DREAM

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Alternative Name: Kcnip3

Background: Csen, Dream, rKChIP3, Kcnip3, Calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, DREAM, Kv channel-interacting protein 3, KChIP3,There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF handcontaining proteins required for the traffic of channel forming Kv4 K+ subunits to the plasma membrane. KChiP3 is also known as calsenilin and as the transcription factor, downstream regulatory element antagonist modulator (DREAM), which regulates a number of genes including prodynorphon. They are highly expressed in the hippocampus. Through its various functions, it may play a role in the regulation of synaptic plasticity, learning and memory.

Gene ID: 65199

NCBI Accession: NP_115851

UniProt: Q9JM47