Recombinant GDF8 (Lintuzumab Biosimilar) antibody

Catalog No. ABIN7543068

The Human Monoclonal anti-GDF8 (Lintuzumab Biosimilar) antibody is suitable to detect GDF8 (Lintuzumab Biosimilar) in samples from Human. It has been validated for Func.

Quick Overview for Recombinant GDF8 (Lintuzumab Biosimilar) antibody (ABIN7543068)

Target: GDF8 (Lintuzumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Human

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Functional Studies (Func)

Clone: SGN-33

Product Details

Purpose: Anti-CD33 [SGN-33 (Lintuzumab)], Human IgG1, kappa

Specificity: This antibody is specific for human CD33, which is restricted to cells of the myelomonocytic lineage. CD33 but does not appear in abundance on normal cells, but is over-expressed in AML and other myeloproliferative diseases.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: This humanized antibody was prepared by combining the CDR regions of the murine anti-CD33 M195 with human framework and constant regions.

Isotype: IgG1 kappa

Application Details

Application Notes: In vitro, this antibody is capable of mediating ADCC against AML cells (Caron, 1998). Though shown to be safe in phase III trials, the use of this antibody in combination with induction chemotherapy did not result in a statistically significant improvement in response rate or survival in patients with refractory/relapsed AML (Feldman, 2005).

Comment:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details

Target: GDF8 (Lintuzumab Biosimilar)

Alternative Name: CD33 (Lintuzumab Biosimilar)

Target Type: Biosimilar

Background: Sialic acid-binding Ig-like lectin 3, gp67, HuM195

UniProt: P20138