Recombinant GDF8 (Lintuzumab Biosimilar) antibody

Catalog No. ABIN7543069

The Rabbit Chimeric anti-GDF8 (Lintuzumab Biosimilar) antibody (Clone SGN-33) (ABIN7543069) specifically detects GDF8 (Lintuzumab Biosimilar) in Func. The antibody is reactive with Human samples.

Quick Overview for Recombinant GDF8 (Lintuzumab Biosimilar) antibody (ABIN7543069)

Target: GDF8 (Lintuzumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: Un-conjugated

Application: Functional Studies (Func)

Clone: SGN-33

Product Details

Purpose: Anti-CD33 [SGN-33 (Lintuzumab)], Rabbit IgG, kappa

Specificity: This antibody is specific for human CD33, which is restricted to cells of the myelomonocytic lineage. CD33 but does not appear in abundance on normal cells, but is over-expressed in AML and other myeloproliferative diseases.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: This humanized antibody was prepared by combining the CDR regions of the murine anti-CD33 M195 with human framework and constant regions.

Isotype: IgG kappa

Application Details

Application Notes: In vitro, this antibody is capable of mediating ADCC against AML cells (Caron, 1998). Though shown to be safe in phase III trials, the use of this antibody in combination with induction chemotherapy did not result in a statistically significant improvement in response rate or survival in patients with refractory/relapsed AML (Feldman, 2005).

Comment:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details

Target: GDF8 (Lintuzumab Biosimilar)

Alternative Name: CD33 (Lintuzumab Biosimilar)

Target Type: Biosimilar

Background: Sialic acid-binding Ig-like lectin 3, gp67, HuM195

UniProt: P20138