Recombinant IDO1 antibody

Catalog No. ABIN7543334

This Rabbit Chimeric antibody specifically detects IDO1 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant IDO1 antibody (ABIN7543334)

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This IDO1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 19C5

Product Details anti-IDO1 Antibody

Purpose: Anti-IDO1 [19C5], Rabbit IgG, kappa

Specificity: This antibody binds an enzyme called indoleamine 2,3-dioxygenase 1 (IDO1). This molecule catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. It is involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. It acts as a suppressor of anti-tumor immunity. IDO1 is the target for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation. Elevated IDO1 expression is a hallmark of major viral and bacterial infections.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: The original antibody was generated by immunizing mice with recombinant human IDO1 protein.

Isotype: IgG kappa

Application Details

Application Notes: This antibody can bind human IDO1 in an ELISA. The original mouse IgG1 antibody binds human IDO1 with an affinity constant of 7.68 X 10^(9) M^(-1). This antibody can be used for the immunohistochemical analysis of various normal and cancerous human tissues like lymph node cells and Hodgkin's lymphoma tissues. The immunohistochemical staining pattern of this antibody is similar to another anti-IDO1 antibody EPR20374 (CN113045667).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for IDO1

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Alternative Name: IDO1

Background: IDO-1, IDO, INDO, Indoleamine 2 3-dioxygenase 1, Indoleamine-pyrrole 2 3-dioxygenase, CGMCC NO 20770, EPR20374

UniProt: P14902

Pathways: Activated T Cell Proliferation