Endothelin 1 antibody

Catalog No. ABIN722766

The Mouse Monoclonal anti-Endothelin 1 antibody (Clone 2C4) (ABIN722766) specifically detects Endothelin 1 in WB, IF (p) and IHC (p). The antibody is reactive with Human and Rat samples.

Quick Overview for Endothelin 1 antibody (ABIN722766)

Target: Endothelin 1 (EDN1)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endothelin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2C4

Product Details anti-Endothelin 1 Antibody

Cross-Reactivity: Human, Rat

Purification: Purified by Protein G.

Immunogen: KLH conjugated synthetic peptide derived from human Endothelin-1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Endothelin 1

Target: Endothelin 1 (EDN1)

Alternative Name: Endothelin-1

Background:

Synonyms: EDN 1, EDN1, EDN1 protein, Endothelin1, ET 1, ET1,

Background: Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms - ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver. Endothelin 1 is expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.

Gene ID: 1906

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size