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Caspase 3 antibody (AA 60-100)

CASP3 Reactivity: Human, Mouse, Rat, Cow, Goat WB, IF (cc) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN724625
  • Target See all Caspase 3 (CASP3) Antibodies
    Caspase 3 (CASP3)
    Binding Specificity
    • 19
    • 16
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 14
    • 13
    • 12
    • 11
    • 10
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 60-100
    Reactivity
    • 278
    • 192
    • 148
    • 30
    • 16
    • 10
    • 10
    • 9
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Goat
    Host
    • 279
    • 40
    • 4
    • 2
    • 2
    Rabbit
    Clonality
    • 273
    • 53
    Polyclonal
    Conjugate
    • 158
    • 26
    • 21
    • 14
    • 11
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    This Caspase 3 antibody is un-conjugated
    Application
    • 251
    • 108
    • 104
    • 85
    • 78
    • 65
    • 52
    • 36
    • 31
    • 29
    • 28
    • 19
    • 10
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
    Cross-Reactivity
    Chicken, Cow, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Caspase 3(Active)
    Isotype
    IgG
  • Application Notes
    WB 1:100-1000
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Zhang, Wang, Li, Yang, Li, Wang: "The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer." in: Aging, Vol. 11, Issue 22, pp. 10284-10300, (2020) (PubMed).

    Li, Li, Xi, Li, Ding, Li: "The effects of photobiomodulation therapy on mouse pre-osteoblast cell line MC3T3-E1 proliferation and apoptosis via miR-503/Wnt3a pathway." in: Lasers in medical science, Vol. 34, Issue 3, pp. 607-614, (2019) (PubMed).

    Chu, Wang, Tang, Shi, Gao, Ma, Lu, Han, Jia, Wang, Adam, Liu, Xiao, Wang, Yang: "Newcastle Disease Virus V Protein Inhibits Cell Apoptosis and Promotes Viral Replication by Targeting CacyBP/SIP." in: Frontiers in cellular and infection microbiology, Vol. 8, pp. 304, (2019) (PubMed).

    Chen, Wang, Chen, Zhang: "Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice." in: Cell and tissue research, Vol. 376, Issue 2, pp. 199-210, (2019) (PubMed).

    Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).

    Wang, Chu, Liu, Pang, Gao, Tang, Ma, Lu, Adam, Dang, Xiao, Wang, Yang: "Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1." in: Veterinary research, Vol. 49, Issue 1, pp. 102, (2018) (PubMed).

    Zheng, Bi, Yang, Zhao, Wang, Li, Zhou: "Hyperglycemia Induced by Chronic Restraint Stress in Mice Is Associated With Nucleus Tractus Solitarius Injury and Not Just the Direct Effect of Glucocorticoids." in: Frontiers in neuroscience, Vol. 12, pp. 983, (2018) (PubMed).

    Abdel-Hamid, El-Azab, Moustafa: "Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 4, pp. 379-395, (2017) (PubMed).

    Ochigbo, Saba, Oyagbemi, Omobowale, Asenuga: "Polyphenol-rich fraction of Parquetina nigrescens mitigates dichlorvos-induced neurotoxicity and apoptosis." in: Journal of Ayurveda and integrative medicine, Vol. 8, Issue 1, pp. 27-36, (2017) (PubMed).

    Kubatka, Uramova, Kello, Kajo, Kruzliak, Mojzis, Vybohova, Adamkov, Jasek, Lasabova, Zubor, Fialova, Dokupilova, Solar, Pec, Adamicova, Danko, Adamek, Busselberg: "Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma." in: Journal of cellular and molecular medicine, (2017) (PubMed).

    Wang, Xuan, Cui, Wang, Chen, Wei, Zhao: "Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes." in: PLoS ONE, Vol. 12, Issue 4, pp. e0173469, (2017) (PubMed).

    He, Chen, Yuan, Zhao, Chen, Wang, Li: "Tumor pH-Responsive Release of Drug-Conjugated Micelles from Fiber Fragments for Intratumoral Chemotherapy." in: ACS applied materials & interfaces, Vol. 9, Issue 38, pp. 32534-32544, (2017) (PubMed).

    Li, Shi, Zhao, Li: "Long noncoding RNA CCAT1 functions as a ceRNA to antagonize the effect of miR-410 on the down-regulation of ITPKB in human HCT-116 and HCT-8 cells." in: Oncotarget, Vol. 8, Issue 54, pp. 92855-92863, (2017) (PubMed).

    Wu, Ye, Zhou, Wang, Xie, Zhang, Gao, Zhang, Zhou, Zhuang, Liu, Hang, Shi: "Roles of Pannexin-1 Channels in Inflammatory Response through the TLRs/NF-Kappa B Signaling Pathway Following Experimental Subarachnoid Hemorrhage in Rats." in: Frontiers in molecular neuroscience, Vol. 10, pp. 175, (2017) (PubMed).

    Xu, Sun, Ren, Yang, Tian, Peng: "Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/β-catenin signaling pathway mediated by Sirt1." in: PLoS ONE, Vol. 12, Issue 10, pp. e0187159, (2017) (PubMed).

    Huang, Fan, Qiu: "TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells." in: International journal of molecular sciences, Vol. 17, Issue 5, (2017) (PubMed).

    Clark, Coury, Meilhac, Petty: "WO3/Pt nanoparticles are NADPH oxidase biomimetics that mimic effector cells in vitro and in vivo." in: Nanotechnology, Vol. 27, Issue 6, pp. 65101, (2016) (PubMed).

    Kubatka, Kello, Kajo, Kruzliak, Výbohová, Mojžiš, Adamkov, Fialová, Veizerová, Zulli, Péč, Statelová, Grančai, Büsselberg: "Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model." in: European journal of nutrition, (2016) (PubMed).

    Yoshinaga, Kajiya, Oishi, Kamada, Ikeda, Chigwechokha, Kibe, Kishida, Kishida, Komatsu, Shiozaki: "NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation." in: European journal of pharmacology, Vol. 782, pp. 21-9, (2016) (PubMed).

  • Target
    Caspase 3 (CASP3)
    Alternative Name
    Caspase 3 (CASP3 Products)
    Synonyms
    CPP32 antibody, CPP32B antibody, SCA-1 antibody, A830040C14Rik antibody, AC-3 antibody, Apopain antibody, CC3 antibody, Caspase-3 antibody, Lice antibody, Yama antibody, mldy antibody, xcpp32 antibody, casp3 antibody, zgc:100890 antibody, CASP-3 antibody, caspase-3 antibody, caspase 3 antibody, caspase 3 S homeolog antibody, caspase 3, apoptosis-related cysteine peptidase a antibody, caspase 3, apoptosis-related cysteine peptidase antibody, CASP3 antibody, Casp3 antibody, casp3.S antibody, casp3a antibody
    Background

    Synonyms: CPP32, SCA-1, CPP32B, Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, CASP3

    Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

    Gene ID
    836
    UniProt
    P42574
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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