Recombinant CRHR2 antibody

Catalog No. ABIN7566415

This Human Monoclonal antibody specifically detects CRHR2 in WB, ELISA, IHC, IF and Func. It exhibits reactivity toward Aspergillus fumigatus.

Quick Overview for Recombinant CRHR2 antibody (ABIN7566415)

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Antibody Type: Recombinant Antibody

Reactivity: Aspergillus fumigatus

Host: Human

Clonality: Monoclonal

Conjugate: This CRHR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Functional Studies (Func)

Clone: MS112-IIA1

Product Details anti-CRHR2 Antibody

Purpose: anti-Crf2 (Aspergillus fumigatus), mAb (rec.) (MS112-IIA1)

Characteristics:

Recombinant Antibody. Recognizes Crf2 from Aspergillus fumigatus. Possible cross-reactivity with Crf1, Crf2 and Asp f9 [Reference 2]. Applications: ELISA, FUNC, IHC, WB, IF. Clone: MS112-IIA1. Isotype: Human IgG1. Formulation: Liquid. In PBS. Aspergillus fumigatus is a common airborne fungal pathogen for humans. It frequently causes an invasive aspergillosis (IA) in immunocompromised patients with poor prognosis. Potent antifungal drugs are very expensive and cause serious adverse effects. Their correct application requires an early and specific diagnosis of IA. Encoded by CRF1 gene, the Crf protein family contains three protein variants: Crf2 protein, amino acids (333 aa) long, Asp f9 protein (292 aa), first identified as an allergen using serum from Aspergillus-allergic patients and Crf1 (395 aa, also named Crh5). The glycosyol hydrolase/glycosidase Crf2 catalyzes the hydrolysis of glycosidic bonds in complex sugars and is located in the cell wall of the growing hyphae. Crf2 may be involved in the remodeling of the cell wall as well, and therefore in the growth and the virulence of the fungus.

Aspergillus fumigatus is a common airborne fungal pathogen for humans. It frequently causes an invasive aspergillosis (IA) in immunocompromised patients with poor prognosis. Potent antifungal drugs are very expensive and cause serious adverse effects. Their correct application requires an early and specific diagnosis of IA. Encoded by CRF1 gene, the Crf protein family contains three protein variants: Crf2 protein, amino acids (333 aa) long, Asp f9 protein (292 aa), first identified as an allergen using serum from Aspergillus-allergic patients and Crf1 (395 aa, also named Crh5). The glycosyol hydrolase/glycosidase Crf2 catalyzes the hydrolysis of glycosidic bonds in complex sugars and is located in the cell wall of the growing hyphae. Crf2 may be involved in the remodeling of the cell wall as well, and therefore in the growth and the virulence of the fungus.

Purification: Puified

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant Crf2 (Aspergillus fumigatus) containing a C-terminal His-tag.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.Please handle under sterile conditions to avoid contamination.

Storage: 4 °C,-20 °C

Storage Comment:

Stable for at least 1 year after receipt when stored at -20°C.

Stable for at least 1 week when stored at +4°C.

Target Details for CRHR2

Target: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Alternative Name: Crf2

UniProt: Q4WI46

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour