TGFB1 antibody (AA 351-390)

Catalog No. ABIN724685

The Rabbit Polyclonal anti-TGFB1 antibody has been validated for WB, ELISA, FACS, IHC (p), IF (p), IF (cc) and IHC (fro). It is suitable to detect TGFB1 in samples from Human, Mouse, Rat, Sheep and Rabbit. There are 16+ publications available.

Quick Overview for TGFB1 antibody (AA 351-390) (ABIN724685)

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reactivity: Human, Mouse, Rat, Sheep, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TGFB1 Antibody

Binding Specificity: AA 351-390

Cross-Reactivity: Human, Mouse, Rabbit, Rat, Sheep

Predicted Reactivity: Dog,Cow,Pig,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TGF-Beta 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TGFB1 antibody (ABIN724685)

Shang, Liu, Liu, Li, Dou, Zhang, Sun, Zhang, Zhu, Mu, Ding, Wen: "Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor-β1." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 4537-4544, (2018) (PubMed).

Mao, Zhang, Qi, Jiang, Wu, Lu, Ainiwaer, Shang, Xu, Hao, Shou, Li, Li, Zhang, Bao, Wen: "Efficacy of radiotherapy for the treatment of cystic echinococcosis in naturally infected sheep." in: Infectious diseases of poverty, Vol. 6, Issue 1, pp. 88, (2017) (PubMed).

Shen, Wu, Wang, Zhao, Zhang, Li, Zhao: "Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis." in: International immunopharmacology, Vol. 46, pp. 16-22, (2017) (PubMed).

Eren, Turgut, Akin, Demir: "The Suppression of Wound Healing Response with Sirolimus and Sunitinib Following Experimental Trabeculectomy in a Rabbit Model." in: Current eye research, Vol. 41, Issue 3, pp. 367-76, (2016) (PubMed).

Xue, Chen, Zhao, Zhao, Duan, Zheng: "The Overexpression of TGF-β and CCN2 in Intrauterine Adhesions Involves the NF-κB Signaling Pathway." in: PLoS ONE, Vol. 10, Issue 12, pp. e0146159, (2016) (PubMed).

Venter, Marques, Santos, Monte-Alto-Costa: "Use of platelet-rich plasma in deep second- and third-degree burns." in: Burns : journal of the International Society for Burn Injuries, Vol. 42, Issue 4, pp. 807-14, (2016) (PubMed).

Ganguly, Wen, Myer, Czech, Sahu, Steinmetz, Raman: "Anti-atherogenic effect of trivalent chromium-loaded CPMV nanoparticles in human aortic smooth muscle cells under hyperglycemic conditions in vitro." in: Nanoscale, Vol. 8, Issue 12, pp. 6542-54, (2016) (PubMed).

Zhu, Hu, Yu, Ren, Hu: "High Molecular Weight Hyaluronic Acid Inhibits Fibrosis of Endometrium." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 22, pp. 3438-3445, (2016) (PubMed).

Du, Niu, Wang, Zhao, Kong, Zhang, Nan: "TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice." in: Molecular medicine reports, Vol. 13, Issue 3, pp. 2159-66, (2016) (PubMed).

Shang, Liu, Liu, Zhang, Mu, Zhu, Liang, Zhai, Ding, Li, Wen: "Acetyl-11-Keto-β-Boswellic Acid Attenuates Prooxidant and Profibrotic Mechanisms Involving Transforming Growth Factor-β1, and Improves Vascular Remodeling in Spontaneously Hypertensive Rats." in: Scientific reports, Vol. 6, pp. 39809, (2016) (PubMed).

Tang, Jiang, Zhou, Xia, Dai: "Increased adenosine levels contribute to ischemic kidney fibrosis in the unilateral ureteral obstruction model." in: Experimental and therapeutic medicine, Vol. 9, Issue 3, pp. 737-743, (2015) (PubMed).

Hu, Zeng, Jiang, Hu, Meng, Zhu, Mao: "The expression of marker for endometrial stem cell and fibrosis was increased in intrauterine adhesious." in: International journal of clinical and experimental pathology, Vol. 8, Issue 2, pp. 1525-34, (2015) (PubMed).

Sun, Li, Wen, Wang, Ji, Ma: "Immunological effect induced by mesenchymal stem cells in a rat liver transplantation model." in: Experimental and therapeutic medicine, Vol. 10, Issue 2, pp. 401-406, (2015) (PubMed).

Abdelmagid, Belcher, Moussa, Lababidi, Sondag, Novak, Sanyurah, Frara, Razmpour, Del Carpio-Cano, Safadi: "Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro." in: The American journal of pathology, Vol. 184, Issue 3, pp. 697-713, (2014) (PubMed).

Erbas, Yapislar, Oltulu, Yavaso?lu, Aktug, Taskiran: "Nephro-protective effect of granulocyte colony-stimulating factor in streptozotocin induced diabetic rats." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 89, Issue 7, pp. 488-96, (2014) (PubMed).

Kou, Hu, Yao, Wang, Shen, Kang, Hong: "Transforming growth factor-?1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 62, Issue 3, pp. 283-9, (2013) (PubMed).

Target Details for TGFB1

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Alternative Name: TGF beta 1

Background:

Synonyms: CED, DPD1, TGFB, TGFbeta, Transforming growth factor beta-1, TGF-beta-1, TGFB1

Background: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

Molecular Weight: 12.8kDa

Gene ID: 7040

UniProt: P01137

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints