CD22 antibody (Elab Fluor®700)

Catalog No. ABIN7566714

The Mouse Monoclonal anti-CD22 antibody has been validated for FACS. It is suitable to detect CD22 in samples from Mouse.

Quick Overview for CD22 antibody (Elab Fluor®700) (ABIN7566714)

Target: CD22 (CD22 Molecule (CD22))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD22 antibody is conjugated to Elab Fluor®700

Application: Flow Cytometry (FACS)

Clone: Cy34-1

Product Details anti-CD22 Antibody (Elab Fluor®700)

Purpose: Elab Fluor®700 Anti-Mouse CD22 Antibody[Cy34.1]

Isotype: IgG2a, kappa

Application Details

Application Notes: Each lot of this antibody is quality control tested by flow cytometric analysis. Applications vary, the appropriate dilutions must be determined for individual use.

Comment:

Matching Isotype Control: E-AB-F09792M1

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Storage: 4 °C

Storage Comment: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Expiry Date: 12 months

Target Details for CD22

Target: CD22 (CD22 Molecule (CD22))

Alternative Name: CD22

Background: Siglec2,B-cell receptor CD22,B-lymphocyte cell adhesion molecule,BL-CAM,CD22,Cd22,Lyb-8,Sialic acid-binding Ig-like lectin 2,Siglec-2,T-cell surface antigen Leu-14,The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig μ chain are augmented in the presence of Cy34.1 mAb.

Gene ID: 12483

UniProt: P35329