BAX antibody (AA 84-175)

Catalog No. ABIN725390

The Rabbit Polyclonal anti-BAX antibody has been validated for WB, ELISA, FACS, IP, IHC (p), IF (cc), IF (p) and IHC (fro). It is suitable to detect BAX in samples from Human, Mouse, Rat, Pig, Cow, Rabbit, Chicken and Zebrafish (Danio rerio). There are 34+ publications available.

Quick Overview for BAX antibody (AA 84-175) (ABIN725390)

Target: BAX (BCL2-Associated X Protein (BAX))

Reactivity: Human, Mouse, Rat, Pig, Cow, Rabbit, Chicken, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAX antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-BAX Antibody

Binding Specificity: AA 84-175

Cross-Reactivity: Chicken, Cow, Human, Mouse, Pig, Rabbit, Rat, Zebrafish (Danio rerio)

Predicted Reactivity: Dog,Cow,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Bax

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-BAX antibody (ABIN725390)

Zeng, Yi, Huang, An, Wang: "Long-term arsenite exposure induces testicular toxicity by redox imbalance, G2/M cell arrest and apoptosis in mice." in: Toxicology, Vol. 411, pp. 122-132, (2019) (PubMed).

Si, Zhou, Zhao, Xie, Gan, Zhang, Wang, Zhou, Ren, Zhang: "Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity." in: Toxicology, Vol. 411, pp. 143-153, (2019) (PubMed).

Liu, Li, Yang, Niu, Zhao, Zhao, Wang: "Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis." in: Biomedicine & pharmacotherapy, Vol. 96, pp. 1363-1370, (2018) (PubMed).

Abdel-Hamid, El-Azab, Moustafa: "Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 4, pp. 379-395, (2017) (PubMed).

Rahman, Ukiana, Uson-Lopez, Sikder, Saito, Kurasaki: "Cytotoxic effects of cadmium and zinc co-exposure in PC12 cells and the underlying mechanism." in: Chemico-biological interactions, Vol. 269, pp. 41-49, (2017) (PubMed).

Liu, Su, Hao, Chen, Liu, Liao, Li: "Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice." in: International journal of molecular sciences, Vol. 17, Issue 1, (2016) (PubMed).

Aksu, Özkaraca, Kandemir, Ömür, Eldutar, Küçükler, Çomaklı: "Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress." in: Andrologia, Vol. 48, Issue 10, pp. 1145-1154, (2016) (PubMed).

Daverey, Agrawal: "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).

Yang, Lu, Guo: "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4075-4082, (2016) (PubMed).

She, Zhao, Zhu, Han, Xia, Bai, Zhang, Li: "Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats." in: Cell biochemistry and biophysics, (2015) (PubMed).

Huang, Zou, Shi, Zhang, Peng, Zhang, Gao, Wang, Zhang: "Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 386012, (2015) (PubMed).

Li, Zhang, Liu, Ren, Song, Rao, Takahashi, Zhou, Li, Chen: "Deficits of learning and memory in Hemojuvelin knockout mice." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, (2015) (PubMed).

Park, Kim, Choi, Heo, Park: "New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro." in: Cellular signalling, Vol. 27, Issue 9, pp. 1831-9, (2015) (PubMed).

He, Han, Hu, Zhang, Hua, Peng: "Canonical Wnt signaling pathway contributes to the proliferation and survival in porcine pancreatic stem cells (PSCs)." in: Cell and tissue research, Vol. 362, Issue 2, pp. 379-88, (2015) (PubMed).

Han, Ji, Chen, Yin, Xu, Li, Chen, Zhu, Peng: "Protective effects of tao-Hong-si-wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 195835, (2015) (PubMed).

Mori, Akita, Tanida, Ishida, Toda, Inoue, Yashiro, Sawada, Hirakawa, Nakada et al.: "MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-κB p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer ..." in: The Journal of biological chemistry, Vol. 289, Issue 51, pp. 35193-204, (2015) (PubMed).

Peng, Fu, Guo, Zhang, Di, Jiang, Li: "Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells I n -v itro." in: Iranian journal of pharmaceutical research : IJPR, Vol. 14, Issue 1, pp. 251-61, (2015) (PubMed).

He, Song, Liu, Chen, Hua: "Rapamycin inhibits acrolein-induced apoptosis by alleviating ROS-driven mitochondrial dysfunction in male germ cells." in: Cell proliferation, Vol. 47, Issue 2, pp. 161-71, (2014) (PubMed).

Ye, Li, Li, Yang, Niu, Wang: "Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo." in: Journal of ethnopharmacology, Vol. 153, Issue 1, pp. 258-67, (2014) (PubMed).

Lin, Wang, Wang, Fang, Zhang, Yang, Guo, Lin, Zhang, Wang: "Lithocarpus polystachyus REHD leaf aqueous extract inhibits human breast cancer growth in vitro and in vivo." in: Nutrition and cancer, Vol. 66, Issue 4, pp. 613-24, (2014) (PubMed).

Target Details for BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Alternative Name: Bax

Background:

Synonyms: BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX

Background: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Gene ID: 581

UniProt: Q07812

Pathways: p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response