NHLRC1 antibody (AA 1-395) (FL594)

Catalog No. ABIN7595676

The Mouse Monoclonal anti-NHLRC1 antibody has been validated for ICC. It is suitable to detect NHLRC1 in samples from Human.

Quick Overview for NHLRC1 antibody (AA 1-395) (FL594) (ABIN7595676)

Target: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NHLRC1 antibody is conjugated to FL594

Application: Immunocytochemistry (ICC)

Clone: N85-18

Product Details anti-NHLRC1 Antibody (FL594)

Binding Specificity: AA 1-395

Purpose: Anti-Malin Antibody FL594 Conjugate

Specificity: No off-targets reported

Cross-Reactivity: Human, Mouse, Non-Human Primate, Rat

Characteristics:

Description: Our Anti-Malin mouse monoclonal primary antibody is produced in-house from hybridoma clone N85/18. It detects human, mouse, non-human primate, rat Malin, and is purified by Protein A chromatography. It is great for use in ICC.

Manufacturer Comment: We produce our Malin mouse monoclonal primary antibody from hybridoma clone N85/18. It is great in ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 1-395 (full-length) of human malin (accession number AAQ19671) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for NHLRC1

Target: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Alternative Name: Malin

Background:

Synonyms: E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1)

Target Description: NHL Repeat Containing E3 Ubiquitin Protein Ligase 1 is encoded by the gene NHLRC1. NHLRC1 is an E3 ubiquitin-protein ligase which is involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. NHLRC1 is expressed in the brain, spinal cord, heart, liver, skeletal muscle, and pancreas. Diseases associated with NHLRC1 include Myoclonic Epilepsy of Lafora and Epilepsy.

Gene Name Alternatives: NHLRC1 EPM2B

Molecular Weight: 42 kDa