CoREST antibody (AA 109-293) (FL594)

Catalog No. ABIN7595686

This anti-CoREST antibody is a Mouse Monoclonal antibody detecting CoREST in IHC and ICC. Suitable for Human.

Quick Overview for CoREST antibody (AA 109-293) (FL594) (ABIN7595686)

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CoREST antibody is conjugated to FL594

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: K72-8

Product Details anti-CoREST Antibody (FL594)

Binding Specificity: AA 109-293

Purpose: Anti-Co-Rest/RCOR1 Antibody FL594 Conjugate

Specificity: No off-targets reported

Cross-Reactivity: Human, Mouse, Rat

Characteristics:

Description: Our Anti-Co-Rest/RCOR1 mouse monoclonal primary antibody is produced in-house from hybridoma clone K72/8. It detects human, mouse, and rat Co-Rest/RCOR1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Co-Rest/RCOR1 mouse monoclonal primary antibody from hybridoma clone K72/8. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 109-293 of human Co-Rest (accession number Q9UKL0), includes ELM2 and SANT domains, produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for CoREST

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Alternative Name: RCOR1

Background:

Synonyms: REST corepressor 1 (Protein CoREST)

Target Description: REST Corepressor 1, CoREST or RCOR is encoded by the gene RCOR1 and is a member of the CoREST family of proteins. CoREST is a corepressor to the RE1 silencing transcription factor/neural restrictive silencing (REST) transcription factor and is part of a multiprotein complex (BHC complex) that represses transcription of neuron-specific genes in non-neuronal cells. This complex determines neural cell differentiation. CoREST is ubiquitously expressed in the nucleus of cells. Diseases associated with this gene include Huntington Disease and Loeys-Dietz Syndrome 1.

Gene Name Alternatives: RCOR1 KIAA0071 RCOR

Molecular Weight: 66-80 kDa (depending on gel system used)

Pathways: Regulation of Hormone Metabolic Process, Chromatin Binding