PINK1 antibody (AA 112-496) (FL594)

Catalog No. ABIN7595687

This Mouse Monoclonal antibody specifically detects PINK1 in IHC and ICC. It exhibits reactivity toward Human.

Quick Overview for PINK1 antibody (AA 112-496) (FL594) (ABIN7595687)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PINK1 antibody is conjugated to FL594

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: N4-15

Product Details anti-PINK1 Antibody (FL594)

Binding Specificity: AA 112-496

Purpose: Anti-Pink1 PTEN Induced Putative Kinase 1 Antibody FL594 Conjugate

Specificity: No off-targets reported

Cross-Reactivity: Human, Mouse, Rat

Characteristics:

Description: Our Anti-Pink1 PTEN induced putative kinase 1 mouse monoclonal primary antibody is produced in-house from hybridoma clone N4/15. It detects human, mouse, and rat Pink1 PTEN induced putative kinase 1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Manufacturer Comment: We produce our Pink1 PTEN induced putative kinase 1 mouse monoclonal primary antibody from hybridoma clone N4/15. It is great in IHC, ICC and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb.

Purity: > 90 % specific antibody

Immunogen: Fusion protein amino acids 112-496 of human Pink1 (accession number NP_115785) produced recombinantly in E. Coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Expiry Date: 12 months

Target Details for PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Alternative Name: Pink1 PTEN induced putative kinase 1

Background:

Synonyms: Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)

Target Description: PTEN Induced Kinase 1 is encoded by the gene PINK1. PINK1 is a member of the protein kinase superfamily, Ser/Thr protein kinase family. PINK1 is a serine/threonine protein kinase that protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. PINK1 is highly expressed in the heart, skeletal muscle, and testis. Diseases associated with PINK1 include Parkinson Disease 6, Autosomal Recessive Early-Onset and Parkinson Disease 2, Autosomal Recessive Juvenile.

Gene Name Alternatives: PINK1

Molecular Weight: 63 kDa

Pathways: Autophagy