FYCO1 antibody (AA 1-1019)

Catalog No. ABIN7598934

This Rabbit Polyclonal antibody specifically detects FYCO1 in WB, ELISA, IHC and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FYCO1 antibody (AA 1-1019) (ABIN7598934)

Target: FYCO1 (FYVE and Coiled-Coil Domain Containing 1 (FYCO1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FYCO1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-FYCO1 Antibody

Binding Specificity: AA 1-1019

Purpose: Anti-FYCO1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-FYCO1 Antibody Picoband® (ABIN7598934). Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FYCO1 recombinant protein (Position: M1-K1019). Human FYCO1 shares 72.2% amino acid (aa) sequence identity with mouse FYCO1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL
1. Chen, J., Ma, Z., Jiao, X., Fariss, R., Kantorow, W. L., Kantorow, M., Pras, E., Frydman, M., Pras, E., Riazuddin, S., Riazuddin, S. A., Hejtmancik, J. F. Mutations in FYCO1 cause autosomal-recessive congenital cataracts. Am. J. Hum. Genet. 88: 827-838, 2011. 2. Kiss, H., Yang, Y., Kiss, C., Andersson, K., Klein, G., Imreh, S., Dumanski, J. P. The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3. Europ. J. Hum. Genet. 10: 52-61, 2002. 3. Pras, E., Pras, E., Bakhan, T., Levy-Nissenbaum, E., Lahat, H., Assia, E. I., Garzozi, H. J., Kastner, D. L., Goldman, B., Frydman, M. A gene causing autosomal recessive cataract maps to the short arm of chromosome 3. Isr. Med. Assoc. J. 3: 559-562, 2001.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for FYCO1

Target: FYCO1 (FYVE and Coiled-Coil Domain Containing 1 (FYCO1))

Alternative Name: FYCO1

Background:

Synonyms: FYCO1, ZFYVE7, FYVE and coiled-coil domain-containing protein 1, Zinc finger FYVE domain-containing protein 7

Background: The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2).

Molecular Weight: 167 kDa

Gene ID: 79443

Pathways: SARS-CoV-2 Protein Interactome