SLFN11 antibody (AA 114-794)

Catalog No. ABIN7599761

The Rabbit Polyclonal anti-SLFN11 antibody is suitable to detect SLFN11 in samples from Human. It has been validated for ELISA, WB, IHC and FACS.

Quick Overview for SLFN11 antibody (AA 114-794) (ABIN7599761)

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLFN11 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-SLFN11 Antibody

Binding Specificity: AA 114-794

Purpose: Anti-SLFN11 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-SLFN11 Antibody. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SLFN11 recombinant protein (Position: P114-D794).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SLFN11

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Alternative Name: SLFN11

Background:

Background: Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.

Gene Full Name: schlafen family member 11

Molecular Weight: 103 kDa

Gene ID: 91607

UniProt: Q7Z7L1