SLFN11 antibody (AA 114-794)

Catalog No. ABIN7870195

The Rabbit Polyclonal anti-SLFN11 antibody (ABIN7870195) specifically detects SLFN11 in ELISA, WB, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for SLFN11 antibody (AA 114-794) (ABIN7870195)

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLFN11 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SLFN11 Antibody

Binding Specificity: AA 114-794

Purpose: SLFN11 Antibody / Schlafen family member 11

Purification: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids P114-D794) was used as the immunogen for the SLFN11 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SLFN11 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SLFN11 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SLFN11

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Alternative Name: SLFN11

Background: Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.

UniProt: Q7Z7L1