Poliovirus Receptor antibody (AA 24-345)

Catalog No. ABIN7600826

The Rabbit Polyclonal anti-Poliovirus Receptor antibody (ABIN7600826) specifically detects Poliovirus Receptor in WB and ELISA. The antibody is reactive with Mouse and Rat samples.

Quick Overview for Poliovirus Receptor antibody (AA 24-345) (ABIN7600826)

Target: Poliovirus Receptor (PVR)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Poliovirus Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Poliovirus Receptor Antibody

Binding Specificity: AA 24-345

Purpose: Anti-Poliovirus Receptor/PVR Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Poliovirus Receptor/PVR Antibody (ABIN7600826). Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Poliovirus Receptor/PVR recombinant protein (Position: R24-R345).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for Poliovirus Receptor

Target: Poliovirus Receptor (PVR)

Alternative Name: PVR

Background:

Synonyms: NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314, KLRK1, D12S2489E, NKG2D

Tissue Specificity: Expressed in natural killer (NK) cells, CD8 (+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).

Background: CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that in humans is encoded by the PVR gene. The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 60-80 kDa

Gene ID: 52118

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome